An abundance of human clinical data reveals that vitamin K plays a essential role in maintaining healthy bone density by facilitating the transport of calcium from the bloodstream into the bone.3-7 Vitamin K may be required by calcium-regulating proteins within the arteries. Matrix Gla-protein (MGP) is a vitamin K-dependent protein, and it should be carboxylated to function properly. Poor vitamin K status leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification.8 Since MGP is a potent local inhibitor of arterial calcification, MGP is very important with regards to the health of all of the cardiovascular system. Without adequate vitamin K, calcium within the blood can bind to the arterial wall resulting in calcification.9,10 As people age, even a subclinical vitamin K deficiency can pose risks to the vascular system. Poor vitamin K status also leads to increased circulating levels of undercarboxylated osteocalcin that may be shown to be associated with increased bone loss in postmenopausal women.
Promotes Arterial Health and Healthy Bones